Human spaceflights were vital to the operation of Mir, allowing crews and equipment to be carried to and from the space station. Mir was visited by a total of 39 crewed missions, comprising 30 Soyuz flights (1 Soyuz-T, 29 Soyuz-TM) and 9 Space Shuttle flights. These missions carried both long-duration crew members flying principal expeditions (ranging from 70 days up to Valeri Polyakov's 14-month stay beginning in January 1994, which still holds the record for the longest continuous spaceflight by a single person) and short-term visitors (who spent about a week aboard the station). Many of the crew who visited Mir used different spacecraft to launch than they did to land; the first such examples were Aleksandr Viktorenko and Muhammed Faris who flew up in Soyuz TM-3 (launched 22 July 1987) and landed a week later in Soyuz TM-2 on 30 July 1987. The largest crew aboard Mir simultaneously (not including Shuttle-Mir missions) was 6, which first occurred with the launch of Soyuz TM-7 on 26 November 1988 and lasted for just over three weeks.

In this list, uncrewed visiting spacecraft are excluded (see List of uncrewed spaceflights to Mir for details), and long-duration crew members are listed in bold. Times are given in Coordinated Universal Time (UTC). "Time docked" refers to the spacecraft and does not necessarily correspond to the crew.